Adjusting drug diffusivity using miscible polymer blends.

  title={Adjusting drug diffusivity using miscible polymer blends.},
  author={Suping Lyu and Randall Sparer and Christopher Hobot and Kiem Dang},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={102 3},
Tuning the release rates of drugs was accomplished with miscible polymer blends. Dexamethasone (DX) was formulated in a miscible polymer blend composed of two poly(ether urethane)s, one in which DX diffuses relatively quickly and the other in which DX diffuses relatively slowly. Matrices that provide drug diffusion coefficients from 7 x 10(-13) to 3 x 10(-19) cm2/s were obtained by adjusting the blend ratio. Tunable diffusion coefficients were also achieved with partially miscible blends, such… CONTINUE READING

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