Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study.

@article{Bonello2008AdjustedCL,
  title={Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study.},
  author={Laurent Bonello and Laurence Camoin-Jau and St{\'e}phane Arqu{\'e}s and Christian Boyer and Dimitri Panagides and Olivier Wittenberg and M C Sim{\'e}oni and Paul T Barragan and Françoise Dignat-George and Francisco Jos{\'e} Paganelli},
  journal={Journal of the American College of Cardiology},
  year={2008},
  volume={51 14},
  pages={
          1404-11
        }
}
OBJECTIVES This study evaluates the clinical impact of adjusting the loading dose of clopidogrel according to vasodilator-stimulated phosphoprotein (VASP) index in patients with clopidogrel resistance undergoing percutaneous coronary intervention (PCI). BACKGROUND Clopidogrel resistance plays a key role in ischemic recurrence after PCI. In vitro tests of clopidogrel resistance can accurately predict major adverse cardiac events after PCI. METHODS In this prospective, randomized, multicenter… CONTINUE READING
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