Adjunctive treatment with mianserin enhances effects of raclopride on cortical dopamine output and, in parallel, its antipsychotic-like effect

@article{Wiker2005AdjunctiveTW,
  title={Adjunctive treatment with mianserin enhances effects of raclopride on cortical dopamine output and, in parallel, its antipsychotic-like effect},
  author={Charlotte Wiker and Love Linn{\'e}r and M. -L. Wadenberg and Torgny H. Svensson},
  journal={Neuropsychiatric Disease and Treatment},
  year={2005},
  volume={1},
  pages={253 - 260}
}
Clinical studies indicate that adjunctive treatment with the antidepressant drug mianserin, a 5-hydroxytryptamine (5-HT)(2A/C) receptor antagonist and an alpha(2)- and alpha(1)-adrenoceptor antagonist, may enhance the effect of conventional antipsychotic drugs in schizophrenia, in particular on negative symptoms such as withdrawal retardation, akathisia, and some aspects of cognitive impairment. Here, we have examined the effect of mianserin in combination with the selective dopamine (DA) D(2/3… CONTINUE READING

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