Adjunctive systemic antimicrobials for the non-surgical treatment of periodontitis.

  title={Adjunctive systemic antimicrobials for the non-surgical treatment of periodontitis.},
  author={Shivi Khattri and Sumanth Kumbargere Nagraj and Ankita Arora and Prashanti Eachempati and Chandan Kumar Kusum and Kishore G. Bhat and Trevor M Johnson and Giovanni Lodi},
  journal={The Cochrane database of systematic reviews},
BACKGROUND Systemic antimicrobials can be used as an adjunct to mechanical debridement (scaling and root planing (SRP)) as a non-surgical treatment approach to manage periodontitis. A range of antibiotics with different dosage and combinations are documented in the literature. The review follows the previous classification of periodontitis as all included studies used this classification. OBJECTIVES To assess the effects of systemic antimicrobials as an adjunct to SRP for the non-surgical… Expand
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Antimicrobial-induced oral dysbiosis exacerbates naturally occurring alveolar bone loss.
  • Brooks A Swanson, Matthew D Carson, +7 authors Chad M Novince
  • Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2021
Periodontitis-mediated alveolar bone loss is caused by dysbiotic shifts in the commensal oral microbiota that upregulate proinflammatory osteoimmune responses. The study purpose was to determineExpand


Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm.
If systemic antimicrobials are indicated in periodontal therapy, they should be adjunctive to mechanical debridement, but there is not enough evidence to support their use withperiodontal surgery. Expand
Clinical Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis.
The data used in this study revealed that the systemic administration of AZM is beneficial compared with SRP on its own for the treatment of chronic periodontitis. Expand
Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta-analysis.
There was a trend that for initially moderate and deep pockets, metronidazole or metronIDazole combined with amoxicillin resulted in clinical improvements that were more pronounced over doxycycline or azithromycin. Expand
Clarithromycin, as an adjunct to non surgical periodontal therapy for chronic periodontitis: a double blinded, placebo controlled, randomized clinical trial.
The utilisation of CLM in combination with SRP improves the efficacy of NSPT in reducing PD, improving CAL and in lessening microbial loads, suggesting that CLM may be beneficial in the non-surgical treatment regimen of chronic periodontitis. Expand
  • T. Oh
  • Medicine
  • The journal of evidence-based dental practice
  • 2018
The test group, which used CHX mouthwash as an adjunct to SRP, showed greater improvement in the means of PD reduction and CAL gain compared to the control group, and the meta‐analysis revealed that the test group had significantly greater improvement only in PD reduction. Expand
Non-surgical periodontal therapy with systemic antibiotics in patients with untreated aggressive periodontitis: a systematic review and meta-analysis.
For the treatment of patients with aggressive periodontitis, systemic antibiotics combined with non-surgical periodontal therapy resulted in a significant additional effect compared to non-Surgical therapy alone and metronidazole + amoxicillin is the most potent antibiotic combination. Expand
Antibiotics/antimicrobials: systemic and local administration in the therapy of mild to moderately advanced periodontitis.
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Compared to placebo, the prescription of empiric adjunctive systemic antibiotics showed a small absolute, although statistically significant, additional reduction in further attachment loss, and both treatments were effective in preventing disease progression. Expand
Chlorhexidine mouthwash as an adjunct to mechanical therapy in chronic periodontitis: A meta-analysis.
Adjunctive use of CHX mouthrinse with mechanical SRP resulted in slightly greater PD reduction than did SRP alone, and clinicians must consider the small additional gain in PD reduction, negligible effect on CAL, and potential for tooth staining when using CHX as an adjunct to SRP in treating chronic periodontitis. Expand
Local versus systemic adjunctive antibiotic therapy in 28 patients with generalized aggressive periodontitis.
The results indicate that the local delivery of tetracycline by a fiber or the systemic administration of amoxicillin/clavulanic acid given 3 months after scaling and root planing produced similar clinical outcomes over the 9-month observation period. Expand