Adjunctive brexpiprazole in patients with major depressive disorder and anxiety symptoms: an exploratory study

@inproceedings{Davis2016AdjunctiveBI,
  title={Adjunctive brexpiprazole in patients with major depressive disorder and anxiety symptoms: an exploratory study},
  author={Lori L. Davis and Ai Ota and Pamela Perry and Kana Tsuneyoshi and Emmanuelle Weiller and Ross A. Baker},
  booktitle={Brain and behavior},
  year={2016}
}
BACKGROUND Major depressive disorder (MDD) with concurrent anxiety symptoms may signal a difficult-to-treat patient. Brexpiprazole is a serotonin-dopamine activity modulator: a partial agonist at 5-HT1A and dopamine D2 receptors at similar potency, and an antagonist at 5-HT2A and noradrenaline alpha1B/2C receptors. The objective of this Phase IIIb study was to explore effectiveness, safety, and tolerability of brexpiprazole adjunctive to antidepressant (ADT) monotherapy in patients with MDD and… CONTINUE READING
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