Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD.

@article{Goldberg2007AdjunctiveAU,
  title={Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD.},
  author={Joseph F Goldberg and Roy H. Perlis and Seyyed Nassir Ghaemi and Joseph R. Calabrese and Charles L. Bowden and Stephen R. Wisniewski and David J. Miklowitz and Gary S. Sachs and Michael E. Thase},
  journal={The American journal of psychiatry},
  year={2007},
  volume={164 9},
  pages={1348-55}
}
OBJECTIVE Practice guidelines have advised against treating patients with antidepressants during bipolar mixed states or dysphoric manias. However, few studies have examined the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antidepressants plus mood stabilizing drugs. METHOD The authors compared outcomes in patients with bipolar disorder who received a mood stabilizing agent with versus without an antidepressant for a bipolar depressive episode… CONTINUE READING
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