Adjunctive alpha2-adrenoceptor blockade enhances the antipsychotic-like effect of risperidone and facilitates cortical dopaminergic and glutamatergic, NMDA receptor-mediated transmission.

@article{Marcus2009AdjunctiveAB,
  title={Adjunctive alpha2-adrenoceptor blockade enhances the antipsychotic-like effect of risperidone and facilitates cortical dopaminergic and glutamatergic, NMDA receptor-mediated transmission.},
  author={Monica Marcus and Charlotte Wiker and Olivia Fr{\aa}nberg and Asa K Konradsson-Geuken and Xavier Langlois and Kent E Jardemark and Torgny H. Svensson},
  journal={The international journal of neuropsychopharmacology},
  year={2009},
  volume={13 7},
  pages={
          891-903
        }
}
Compared to both first- and second-generation antipsychotic drugs (APDs), clozapine shows superior efficacy in treatment-resistant schizophrenia. In contrast to most APDs clozapine possesses high affinity for alpha2-adrenoceptors, and clinical and preclinical studies provide evidence that the alpha2-adrenoceptor antagonist idazoxan enhances the antipsychotic efficacy of typical D2 receptor antagonists as well as olanzapine. Risperidone has lower affinity for alpha2-adrenoceptors than clozapine… CONTINUE READING

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