Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model

@inproceedings{Subbian2016AdjunctivePI,
  title={Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model},
  author={Selvakumar Subbian and Liana Georgieva Tsenova and Jennifer Holloway and Blas Peixoto and Paul W O'Brien and Veronique Anne Dartois and Vikram Khetani and Jerome B. Zeldis and Gilla Kaplan},
  booktitle={EBioMedicine},
  year={2016}
}
OBJECTIVES Adjunctive host-directed therapy is emerging as a new potential approach to improve the outcome of conventional antimicrobial treatment for tuberculosis (TB). We tested the ability of a phosphodiesterase-4 inhibitor (PDE4i) CC-11050, co-administered with the first-line anti-TB drug isoniazid (INH), to accelerate bacillary killing and reduce chronic inflammation in the lungs of rabbits with experimental Mycobacterium tuberculosis (Mtb) infection. METHODS A rabbit model of pulmonary… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 9 times over the past 90 days. VIEW TWEETS
7 Citations
53 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Aerosol exposure system for rabbits: application to M. tuberculosis infection

  • L.H.R. Tsenova, E. Ellison, C. Manca, G. Kaplan
  • Appl. Biosaf
  • 2006
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…