Adjunctive Minocycline in Clozapine-Treated Schizophrenia Patients With Persistent Symptoms.

  title={Adjunctive Minocycline in Clozapine-Treated Schizophrenia Patients With Persistent Symptoms.},
  author={Deanna Lynn Kelly and Kelli M. Sullivan and J P Mcevoy and Robert Patrick McMahon and Heidi J . Wehring and James M. Gold and Fang Liu and Dale Warfel and Gopal Vyas and Charles Michael Richardson and Bernard A. Fischer and William Ryan Keller and Maju Mathew Koola and S Feldman and Jessica C Russ and Richard S. E. Keefe and Jennifer Osing and Leeka Hubzin and Sharon M August and Trina M. Walker and Robert W. Buchanan},
  journal={Journal of clinical psychopharmacology},
  volume={35 4},
OBJECTIVE Clozapine is the most effective antipsychotic for treatment refractory people with schizophrenia, yet many patients only partially respond. Accumulating preclinical and clinical data suggest benefits with minocycline. We tested adjunct minocycline to clozapine in a 10-week, double-blind, placebo-controlled trial. Primary outcomes tested were positive, and cognitive symptoms, while avolition, anxiety/depression, and negative symptoms were secondary outcomes. METHODS Schizophrenia and… CONTINUE READING
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