Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis.

  title={Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis.},
  author={Justin Beardsley and Marcel Wolbers and Freddie Mukasa Kibengo and Abu-Baker M Ggayi and Anatoli Kamali and Ngo Thi Kim Cuc and Tran Quang Binh and Nguyen van Vinh Chau and Jeremy J. Farrar and Laura Merson and Lan Phuong and Guy Thwaites and Nguyen van Kinh and Pham Thi Thanh Thuy and Wirongrong Chierakul and Suwatthiya Siriboon and Ekkachai Thiansukhon and Satrirat Onsanit and Watthanapong Supphamongkholchaikul and Adrienne K Chan and Robert Heyderman and Edson Mwinjiwa and Joep J. van Oosterhout and Darma Imran and Hasan Basri and Mayfong Mayxay and David A B Dance and Prasith Phimmasone and Sayaphet Rattanavong and David G Lalloo and Jeremy N Day},
  journal={The New England journal of medicine},
  volume={374 6},
BACKGROUND Cryptococcal meningitis associated with human immunodeficiency virus (HIV) infection causes more than 600,000 deaths each year worldwide. Treatment has changed little in 20 years, and there are no imminent new anticryptococcal agents. The use of adjuvant glucocorticoids reduces mortality among patients with other forms of meningitis in some populations, but their use is untested in patients with cryptococcal meningitis. METHODS In this double-blind, randomized, placebo-controlled… CONTINUE READING
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