Adjacent genes, for COL2A1 and the vitamin D receptor, are associated with separate features of radiographic osteoarthritis of the knee.

@article{Uitterlinden2000AdjacentGF,
  title={Adjacent genes, for COL2A1 and the vitamin D receptor, are associated with separate features of radiographic osteoarthritis of the knee.},
  author={Andr{\'e} G. Uitterlinden and H. Burger and Cornelia M van Duijn and Qi-ren Huang and Albert Hofman and Jan C. Birkenh{\"a}ger and Johannes P. T. M van Leeuwen and Huibert A. P. Pols},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 7},
  pages={1456-64}
}
OBJECTIVE To study the association of the COL2A1 genotype, in relation to the vitamin D receptor (VDR) genotype, with features of radiographic osteoarthritis (ROA) in a population of elderly men and women. METHODS In this cross-sectional study, we analyzed a population-based sample of 851 men and women ages 55-80 years from a large cohort study, the Rotterdam Study. We determined the prevalence of ROA of the knee according to the Kellgren/Lawrence (K/L) score and features of ROA (presence of… CONTINUE READING