Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues.

@article{Ortiz1997AdjacentDE,
  title={Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues.},
  author={Benjamin D. Ortiz and Dragana Cado and Vivian Yan Chen and Pierre Diaz and Astar Winoto},
  journal={The EMBO journal},
  year={1997},
  volume={16 16},
  pages={5037-45}
}
Locus control regions (LCRs) are thought to provide a dominant tissue-specific open chromatin domain that allows for proper gene regulation by enhancers/silencers and their associated transcription factors. Expression of the T-cell receptor alpha (TCR alpha) gene is limited to T cells and its locus exists in different chromatin configurations in expressing and nonexpressing cell types. Here we show that eight DNase I-hypersensitive sites in the TCR alpha locus comprise an LCR that confers T… CONTINUE READING

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A dominant chromatin - openinggel - purified prior to hybridization . activity in 5  hypersensitive site 3 of the human β - globin locus control region

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