Adipostatins A and B, new inhibitors of glycerol-3-phosphate dehydrogenase.

  title={Adipostatins A and B, new inhibitors of glycerol-3-phosphate dehydrogenase.},
  author={Nobuaki Tsuge and Masashi Mizokami and Shinichi Imai and Akira Shimazu and Haruo Seto},
  journal={The Journal of antibiotics},
  volume={45 6},
As a result of screening for inhibitors of glycerol-3-phosphate dehydrogenase, which may be effective to prevent corpulence, we isolated two inhibitors named adipostatin A and adipostatin B from the culture broth of Streptomyces cyaneus 2299-SV1. Their structures have been established to be 5-n-pentadecylresorcinol and 5-isopentadecylresorcinol, respectively. Adipostatin A and adipostatin B inhibited glycerol-3-phosphate dehydrogenase at the IC50 values of 4.1 microM and 4.5 microM… CONTINUE READING

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