Adiposity-related protection of intestinal tumorigenesis: interaction with dietary calcium.

@article{Ding2007AdiposityrelatedPO,
  title={Adiposity-related protection of intestinal tumorigenesis: interaction with dietary calcium.},
  author={Sheng-li Ding and Michael F. McEntee and Jay Whelan and Michelle Zemel},
  journal={Nutrition and cancer},
  year={2007},
  volume={58 2},
  pages={153-61}
}
Although high-calcium diets have been reported to reduce the risk of colorectal cancer, our preliminary data with the adenomatous polyposis coli (Apc) Min mutation (Min/+;Apc(Min/+)) mouse shows a paradoxical increase in intestinal tumor loads (> 65%) with high calcium diets. Since we previously demonstrated that increasing dietary calcium reduces adiposity, and Apc(Min/+) mice on high calcium diets exhibited profound loss of adipose tissue, we hypothesized that loss of an adipose tissue… CONTINUE READING

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