Adiposity and metabolic dysfunction in polycystic ovary syndrome

  title={Adiposity and metabolic dysfunction in polycystic ovary syndrome},
  author={Susan Sam},
  journal={Hormone Molecular Biology and Clinical Investigation},
  pages={107 - 116}
  • Susan Sam
  • Published 1 February 2015
  • Medicine, Biology
  • Hormone Molecular Biology and Clinical Investigation
Abstract Polycystic ovary syndrome (PCOS) is the most common hormonal disorder among reproductive-age women and is associated with a high risk for metabolic disorders. Adiposity and insulin resistance are two prevalent conditions in PCOS and the likely culprits for the heightened metabolic risk. Up to 60% of women with PCOS are considered to be overweight or obese, and even among non-obese women with PCOS there is an increased accumulation of adipose tissue in abdominal depots. Insulin… 

Metabolic compromise in women with PCOS: earlier than expected.

Considering the high prevalence of MetS or altered metabolic components in PCOS patients at the moment of the diagnosis, its regular screening is necessary to reduce the mortality and morbidity rates in these women.

Treatment Strategies for the Infertile Polycystic Ovary Syndrome Patient

The ‘short’, antagonist-based protocol is the preferred option for PCOS patients, as it is associated with lower risk of developing ovarian hyperstimulation syndrome (specifically by using a gonadotropin-releasing hormone agonist as ovulation trigger), but with comparable outcomes as the long protocol.

Evaluation of the relationship between serum ferritin and insulin resistance and visceral adiposity index (VAI) in women with polycystic ovary syndrome

According to the results of this study, women with PCOS have a worse metabolic status than women without PCOS, however, this has been shown only in overweight and obese women, not in women with normal weight.

Analysis of secreted peptidome from omental adipose tissue in polycystic ovarian syndrome patients

The results provide a deeper understanding of adipose tissue‐derived peptides in PCOS for future functional studies and demonstrate that these cleavage products are not degradation products of the proteasome based on previous studies reported.

Serum Osteoprotegerin is Diminished in the Polycystic Ovary Syndrome and Associated with Insulin Resistance

Osteoprotegerin (OPG), an osteoclastogenesis inhibitor, has recently been related to metabolic and vascular disorders suggesting a possible link between OPG, PCOS and IR.

The impact of insulin resistance on clinical, hormonal and metabolic parameters in lean women with polycystic ovary syndrome

Comparison of group means showed significantly higher values for waist-to-hip ratio (WHR), diastolic blood pressure and Ferriman–Gallwey score (FGS) in IR’s+ group, and HOMA-IR values were found to be positively correlated with WHR.

Evaluation of Carotid Artery Intima-Media Thickness as a Cardiovascular Risk Factor in Patients With Polycystic Ovary Syndrome

In the PCOS group, when compared to the healthy subjects, dyslipidemia, HbA1c, waist to hip ratio, and CIMT were significantly different, and it might be suitable to perform an ultrasound for CimT in patients with higher Ferriman-Gallwey (FG) score.

MicroRNA-141 and MicroRNA-200c Are Overexpressed in Granulosa Cells of Polycystic Ovary Syndrome Patients

It is demonstrated that the expressions of bothmiR-141 and miR-200c were significantly increased in PCOS patients, which might contribute to the pathogenesis of PCOS.

Transcriptional and DNA Methylation Signatures of Subcutaneous Adipose Tissue and Adipose-Derived Stem Cells in PCOS Women

The data suggest that ASCs play an important role in the etiology of PCOS, potentially by limiting expansion of the healthy lower-body AT.

Quantification of visceral adipose tissue in polycystic ovary syndrome: dual-energy X-ray absorptiometry versus magnetic resonance imaging

DXA showed high reproducibility making it is suitable for repeated measurements in the same individual over time, and DXA-VAT was superior to waist circumference and BMI in estimating MRI-Vat.



Adipose Tissue Dysfunction in Polycystic Ovary Syndrome

The available data indicate that adipose tissue dysfunction plays a central role in the metabolic abnormalities observed in PCOS, which is a common endocrine and metabolic disorder among premenopausal women.

Role of obesity and adiposity in polycystic ovary syndrome

It has been shown that weight loss improves the metabolic and reproductive abnormalities that characterise the syndrome, and it is recommended that women with PCOS follow a Mediterranean diet.

Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome.

It is concluded that the MBS and its components are common in women with PCOS, placing them at increased risk for cardiovascular disease and different features that may reflect more severe insulin resistance.

Adipocyte biology in polycystic ovary syndrome

Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome.

Within a large, community-based population receiving health care, diagnosed PCOS was highly prevalent and associated with a much higher frequency of cardiovascular risk factors that varied by race/ethnicity.

Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.

Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected women have marked

Polycystic ovary syndrome

This Primer summarizes the current state of knowledge regarding the epidemiology, mechanisms and pathophysiology, diagnosis, screening and prevention, management and future investigational directions of the disorder.

Abdominal adiposity and the polycystic ovary syndrome

The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis

It is suggested that prevention and treatment of obesity is important for the management of PCOS and central obesity was associated with higher fasting insulin levels.

Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome.

It is suggested that both the reproductive and metabolic abnormalities persist with age in PCOS, and obese mothers have a very high prevalence of metabolic syndrome.