Adiposity and metabolic dysfunction in polycystic ovary syndrome

@article{Sam2015AdiposityAM,
  title={Adiposity and metabolic dysfunction in polycystic ovary syndrome},
  author={Susan Sam},
  journal={Hormone Molecular Biology and Clinical Investigation},
  year={2015},
  volume={21},
  pages={107 - 116}
}
  • Susan Sam
  • Published 1 February 2015
  • Medicine, Biology
  • Hormone Molecular Biology and Clinical Investigation
Abstract Polycystic ovary syndrome (PCOS) is the most common hormonal disorder among reproductive-age women and is associated with a high risk for metabolic disorders. Adiposity and insulin resistance are two prevalent conditions in PCOS and the likely culprits for the heightened metabolic risk. Up to 60% of women with PCOS are considered to be overweight or obese, and even among non-obese women with PCOS there is an increased accumulation of adipose tissue in abdominal depots. Insulin… 
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22 Citations

Metabolic compromise in women with PCOS: earlier than expected.

TLDR
Considering the high prevalence of MetS or altered metabolic components in PCOS patients at the moment of the diagnosis, its regular screening is necessary to reduce the mortality and morbidity rates in these women.

Treatment Strategies for the Infertile Polycystic Ovary Syndrome Patient

TLDR
The ‘short’, antagonist-based protocol is the preferred option for PCOS patients, as it is associated with lower risk of developing ovarian hyperstimulation syndrome (specifically by using a gonadotropin-releasing hormone agonist as ovulation trigger), but with comparable outcomes as the long protocol.

Evaluation of the relationship between serum ferritin and insulin resistance and visceral adiposity index (VAI) in women with polycystic ovary syndrome

TLDR
According to the results of this study, women with PCOS have a worse metabolic status than women without PCOS, however, this has been shown only in overweight and obese women, not in women with normal weight.

Analysis of secreted peptidome from omental adipose tissue in polycystic ovarian syndrome patients

TLDR
The results provide a deeper understanding of adipose tissue‐derived peptides in PCOS for future functional studies and demonstrate that these cleavage products are not degradation products of the proteasome based on previous studies reported.

Serum Osteoprotegerin is Diminished in the Polycystic Ovary Syndrome and Associated with Insulin Resistance

TLDR
Osteoprotegerin (OPG), an osteoclastogenesis inhibitor, has recently been related to metabolic and vascular disorders suggesting a possible link between OPG, PCOS and IR.

The impact of insulin resistance on clinical, hormonal and metabolic parameters in lean women with polycystic ovary syndrome

TLDR
Comparison of group means showed significantly higher values for waist-to-hip ratio (WHR), diastolic blood pressure and Ferriman–Gallwey score (FGS) in IR’s+ group, and HOMA-IR values were found to be positively correlated with WHR.

Evaluation of Carotid Artery Intima-Media Thickness as a Cardiovascular Risk Factor in Patients With Polycystic Ovary Syndrome

TLDR
In the PCOS group, when compared to the healthy subjects, dyslipidemia, HbA1c, waist to hip ratio, and CIMT were significantly different, and it might be suitable to perform an ultrasound for CimT in patients with higher Ferriman-Gallwey (FG) score.

MicroRNA-141 and MicroRNA-200c Are Overexpressed in Granulosa Cells of Polycystic Ovary Syndrome Patients

TLDR
It is demonstrated that the expressions of bothmiR-141 and miR-200c were significantly increased in PCOS patients, which might contribute to the pathogenesis of PCOS.

Transcriptional and DNA Methylation Signatures of Subcutaneous Adipose Tissue and Adipose-Derived Stem Cells in PCOS Women

TLDR
The data suggest that ASCs play an important role in the etiology of PCOS, potentially by limiting expansion of the healthy lower-body AT.

Quantification of visceral adipose tissue in polycystic ovary syndrome: dual-energy X-ray absorptiometry versus magnetic resonance imaging

TLDR
DXA showed high reproducibility making it is suitable for repeated measurements in the same individual over time, and DXA-VAT was superior to waist circumference and BMI in estimating MRI-Vat.

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TLDR
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