Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin.

@article{Kershaw2006AdiposeTL,
  title={Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin.},
  author={Erin E Kershaw and Jonathan K. Hamm and Linda A. W. Verhagen and Odile Peroni and Ma{\vs}a Kati{\'c} and Jeffrey S. Flier},
  journal={Diabetes},
  year={2006},
  volume={55 1},
  pages={148-57}
}
Adipose triglyceride lipase (ATGL) is a recently described adipose-enriched protein with triglyceride-specific lipase activity. ATGL shares the greatest sequence homology with adiponutrin, a nutritionally regulated protein of unclear biological function. Here we present a functional analysis of ATGL and adiponutrin and describe their regulation by insulin. Retroviral-mediated overexpression of ATGL in 3T3-L1 adipocytes increased basal and isoproterenol-stimulated glycerol and nonesterified… CONTINUE READING
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