Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance.

@article{Kern2001AdiposeTT,
  title={Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance.},
  author={Philip A. Kern and Subramanian Ranganathan and C Li and L Wood and Gouri Ranganathan},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={280 5},
  pages={
          E745-51
        }
}
Adipose tissue expresses tumor necrosis factor (TNF) and interleukin (IL)-6, which may cause obesity-related insulin resistance. We measured TNF and IL-6 expression in the adipose tissue of 50 lean and obese subjects without diabetes. Insulin sensitivity (S(I)) was determined by an intravenous glucose tolerance test with minimal-model analysis. When lean [body mass index (BMI) <25 kg/m(2)] and obese (BMI 30-40 kg/m(2)) subjects were compared, there was a 7.5-fold increase in TNF secretion (P… 
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