Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance.

@article{Kern2001AdiposeTT,
  title={Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance.},
  author={Philip A. Kern and Subramanian Ranganathan and C Li and L Wood and Gouri Ranganathan},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={280 5},
  pages={
          E745-51
        }
}
Adipose tissue expresses tumor necrosis factor (TNF) and interleukin (IL)-6, which may cause obesity-related insulin resistance. We measured TNF and IL-6 expression in the adipose tissue of 50 lean and obese subjects without diabetes. Insulin sensitivity (S(I)) was determined by an intravenous glucose tolerance test with minimal-model analysis. When lean [body mass index (BMI) <25 kg/m(2)] and obese (BMI 30-40 kg/m(2)) subjects were compared, there was a 7.5-fold increase in TNF secretion (P… 
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References

SHOWING 1-10 OF 54 REFERENCES
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.
TLDR
The data suggest that endogenous TNF expression in adipose tissue may help limit obesity in some subjects, perhaps by increasing insulin resistance and decreasing LPL.
Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue.
TLDR
In conclusion, adipose TNF-alpha may be an important specific and local factor in adipose tissue that influences the ability of insulin to stimulate glucose transport in human fat cells, at least in obese women.
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
TLDR
A role for the abnormal regulation of this cytokine in the pathogenesis of obesity-related insulin resistance is suggested as well as the effects of weight reduction by dietary treatment of obesity on the adipose expression of TNF-alpha mRNA.
Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss.
TLDR
Results suggest that, as for leptin, circulating IL-6 concentrations reflect, at least in part, adipose tissue production reduced after weight loss, and could play a role in the improved sensitivity to insulin observed in these patients.
Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.
TLDR
Although both IL-6 and TNF alpha are expressed by adipose tissue, the results show that there are important differences in their systemic release.
Relationship between plasma leptin levels and the tumor necrosis factor-α system in obese subjects
TLDR
The results are consistent with the hypothesis that the TNFα system could be involved in the regulation of plasma leptin concentrations in obese subjects.
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
TLDR
A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Tumor necrosis factor-alpha-induced insulin resistance in adipocytes.
  • C. Qi, P. Pekala
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 2000
TLDR
A review of studies examining the link between insulin resistance and the development of obesity and noninsulin-dependent diabetes mellitus are consistent with the involvement of tumor necrosis factor-alpha (TNF-alpha) as a central mediator, and the molecular aspects of this cytokine, its receptors as well as TNF- alpha-initiated signaling cascades are introduced.
Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link
TLDR
The results strongly suggest that TNF-α may play a crucial role in the systemic insulin resistance of NIDDM, and may allow for new treatments of disorders involving resistance to insulin.
Tumor Necrosis Factor-α in Sera of Obese Patients: Fall with Weight Loss
TLDR
This study investigated whether serum TNFα concentrations are elevated in obese subjects, whether they fall after weight loss, and whether this fall parallels the fall in insulin release after glucose challenge.
...
1
2
3
4
5
...