Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance.

  title={Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance.},
  author={P. Kern and S. Ranganathan and C. Li and L. Wood and G. Ranganathan},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={280 5},
  • P. Kern, S. Ranganathan, +2 authors G. Ranganathan
  • Published 2001
  • Medicine
  • American journal of physiology. Endocrinology and metabolism
  • Adipose tissue expresses tumor necrosis factor (TNF) and interleukin (IL)-6, which may cause obesity-related insulin resistance. We measured TNF and IL-6 expression in the adipose tissue of 50 lean and obese subjects without diabetes. Insulin sensitivity (S(I)) was determined by an intravenous glucose tolerance test with minimal-model analysis. When lean [body mass index (BMI) <25 kg/m(2)] and obese (BMI 30-40 kg/m(2)) subjects were compared, there was a 7.5-fold increase in TNF secretion (P… CONTINUE READING
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