Adipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat.

@article{Hainault2002AdiposeTI,
  title={Adipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat.},
  author={Isabelle Hainault and Guillaume Nebout and Sophie Turban and Bernadette Ardouin and Pascal Ferr{\'e} and Annie Quignard-Boulang{\'e}},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={282 1},
  pages={E59-66}
}
We investigated angiotensinogen (AGT) expression in adipose tissue and liver of Zucker rats during the onset of obesity. The developmental pattern of AGT expression (protein and mRNA) in liver was similar in both genotypes. In inguinal adipose tissue, AGT cell content was similar in suckling and weaned pups in lean rats, whereas it continuously increased with age in obese rats. AGT amount in adipocytes was unaffected by the genotype until weaning. Thereafter, adipocytes from obese rats… CONTINUE READING