Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes

@inproceedings{Kovov2016AdiposeTN,
  title={Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes},
  author={Zuzana Kov{\'a}{\vc}ov{\'a} and William G. Tharp and Dianxin Liu and Wan Wei and Hui Xie and Sheila Collins and Richard E. Pratley},
  booktitle={Obesity},
  year={2016}
}
OBJECTIVE Cardiac natriuretic peptides (NPs) bind to two receptors (NPRA-mediator of signaling; NPRC-clearance receptor) whose ratio, NPRR (NPRA/NPRC), determines the NP bioactivity. This study investigated the relationship of NP receptor gene expression in adipose tissue and muscle with obesity and glucose intolerance. Prospectively, the study also assessed whether changes in NP receptor expression and thermogenic gene markers accompanied improvements of insulin sensitivity. METHODS A cross… CONTINUE READING
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