Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice.

@article{Bijnen2018AdiposeTM,
  title={Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice.},
  author={Mitchell Bijnen and Tatjana Josefs and Ilona Cuijpers and Constantijn J Maalsen and Jos{\'e} van de Gaar and Maria Vroomen and Erwin Wijnands and Sander S Rensen and Jan Willem W. M. Greve and Marten H. Hofker and Erik A. L. Biessen and Coen D A Stehouwer and Casper G Schalkwijk and Kristiaan Wouters},
  journal={Gut},
  year={2018},
  volume={67 7},
  pages={
          1317-1327
        }
}
OBJECTIVE Obesity is a risk factor for non-alcoholic steatohepatitis (NASH). This risk has been attributed to visceral adipose tissue (vAT) expansion associated with increased proinflammatory mediators. Accumulation of CD11c+ proinflammatory adipose tissue macrophages (ATM) is an important driver of vAT inflammation. We investigated the role of ATMs in hepatic inflammation during NASH development. DESIGN vAT isolated from lean, obese or ATM-depleted (using clodronate liposomes) obese mice was… CONTINUE READING
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revision of the human hematopoietic tree : granulocyte subtypes derive from distinct hematopoietic lineages

  • görgens a, S radtke, M Möllmann
  • Cell Rep
  • 2013

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