Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity.

@article{Thorn2017AdiposeTI,
  title={Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity.},
  author={Clare E Thorn and B. Knight and E. Pastel and L. McCulloch and B. Patel and A. Shore and K. Kos},
  journal={Diabetes & metabolism},
  year={2017},
  volume={43 3},
  pages={
          240-247
        }
}
  • Clare E Thorn, B. Knight, +4 authors K. Kos
  • Published 2017
  • Biology, Medicine
  • Diabetes & metabolism
  • AIMS Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular risk and diabetes independent of obesity. We investigated whether adipose tissue dysfunction is exacerbated due to increased tissue hypoxia. METHODS Adipose tissue (AT) oxygenation was measured with a Clarke-type electrode (pATO2) in 16 men with OSAS before and after 4 months of continuous positive airway pressure therapy (CPAP) and in BMI-matched controls. Oxygenation was simultaneously monitored in… CONTINUE READING
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    Paper Mentions

    OBSERVATIONAL CLINICAL TRIAL
    Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea… Expand
    ConditionsHypoxia, Obesity, Obstructive Sleep Apnoea
    InterventionDevice
    Obesity, sleep apnea, and cancer
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    Intermittent Hypoxia Up-Regulates CCL2, RETN, and TNFα mRNAs in Adipocytes via Down-regulation of miR-452
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    Lysyl oxidase and adipose tissue dysfunction.
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    Technical Feasibility and Physiological Relevance of Hypoxic Cell Culture Models
    • 2
    • Highly Influenced
    • PDF

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