Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity.

  title={Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity.},
  author={Clare E Thorn and B. Knight and E. Pastel and L. McCulloch and B. Patel and A. Shore and K. Kos},
  journal={Diabetes & metabolism},
  volume={43 3},
  • Clare E Thorn, B. Knight, +4 authors K. Kos
  • Published 2017
  • Biology, Medicine
  • Diabetes & metabolism
  • AIMS Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular risk and diabetes independent of obesity. We investigated whether adipose tissue dysfunction is exacerbated due to increased tissue hypoxia. METHODS Adipose tissue (AT) oxygenation was measured with a Clarke-type electrode (pATO2) in 16 men with OSAS before and after 4 months of continuous positive airway pressure therapy (CPAP) and in BMI-matched controls. Oxygenation was simultaneously monitored in… CONTINUE READING
    10 Citations

    Paper Mentions

    Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea… Expand
    ConditionsHypoxia, Obesity, Obstructive Sleep Apnoea
    Obesity, sleep apnea, and cancer
    • 5
    Obstructive Sleep Apnea Syndrome and Metabolic Diseases
    • 17
    • PDF
    Intermittent hypoxia, energy expenditure, and visceral adipocyte recovery
    • 2
    Intermittent Hypoxia Up-Regulates CCL2, RETN, and TNFα mRNAs in Adipocytes via Down-regulation of miR-452
    • 10
    • Highly Influenced
    • PDF
    Lysyl oxidase and adipose tissue dysfunction.
    • 11
    Technical Feasibility and Physiological Relevance of Hypoxic Cell Culture Models
    • 2
    • Highly Influenced
    • PDF


    Effects of different acute hypoxic regimens on tissue oxygen profiles and metabolic outcomes.
    • 132
    • PDF
    Metabolic Signatures of Human Adipose Tissue Hypoxia in Obesity
    • 92
    • PDF
    Increased Adipose Tissue Oxygen Tension in Obese Compared With Lean Men Is Accompanied by Insulin Resistance, Impaired Adipose Tissue Capillarization, and Inflammation
    • 224
    • Highly Influential
    CPAP for the metabolic syndrome in patients with obstructive sleep apnea.
    • 333
    • PDF
    Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
    • 1,050
    • PDF
    Acute hypoxia induces hypertriglyceridemia by decreasing plasma triglyceride clearance in mice.
    • 57
    Biological plausibility linking sleep apnoea and metabolic dysfunction
    • 61
    • PDF