Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n−3 polyunsaturated fatty acids

@article{Todoric2006AdiposeTI,
  title={Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n−3 polyunsaturated fatty acids},
  author={Jelena Todoric and Markus Loeffler and Joakim Huber and Martin Bilban and Mark Reimers and Alexandra Kadl and Maximilian Zeyda and Werner Waldh{\"a}usl and Thomas Michael Stulnig},
  journal={Diabetologia},
  year={2006},
  volume={49},
  pages={2109-2119}
}
Inflammatory alterations in white adipose tissue appear to underlie complications of obesity including diabetes mellitus. Polyunsaturated fatty acids (PUFA), particularly those of the n−3 series, modulate immune responses and may ameliorate insulin sensitivity. In this study, we investigated how PUFA affect white adipose tissue inflammation and gene expression in obese diabetic animals. We treated db/db mice as well as lean non-diabetic mice (db/+) with either low-fat standard diet (LF) or high… CONTINUE READING
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