Adipose tissue inflammation and adiponectin resistance in patients with advanced heart failure: correction after ventricular assist device implantation.

@article{Khan2012AdiposeTI,
  title={Adipose tissue inflammation and adiponectin resistance in patients with advanced heart failure: correction after ventricular assist device implantation.},
  author={Raffay S. Khan and Tomoko Sugiyama Kato and Aalap Chokshi and Michael Chew and Shuiqing Yu and Christina Sing-Ying Wu and Parvati Singh and Faisal Habib Cheema and Hiroo Takayama and Collette R Harris and Gissette Reyes-Soffer and Ralph Knoell and Hendrik Milting and Yoshifumi Naka and Donna M. Mancini and Paul Christian Schulze},
  journal={Circulation. Heart failure},
  year={2012},
  volume={5 3},
  pages={340-8}
}
BACKGROUND Heart failure (HF) is characterized by inflammation, insulin resistance, and progressive catabolism. We hypothesized that patients with advanced HF also develop adipose tissue inflammation associated with impaired adipokine signaling and that hemodynamic correction through implantation of ventricular assist devices (VADs) would reverse adipocyte activation and correct adipokine signaling in advanced HF. METHODS AND RESULTS Circulating insulin, adiponectin, leptin, and resistin… CONTINUE READING

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