Adipose tissue gene expression in patients with a loss of function mutation in the leptin receptor

BACKGROUND: In order to maintain body weight regulation, leptin directly or indirectly signals nutritional changes to key organs, but little is known about its target genes in human adipose tissue. Leptin receptor loss of function is a unique way to explore the role of leptin in the regulation of adipose tissue.OBJECTIVE: We studied the consequences of the… CONTINUE READING