Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells

@inproceedings{Hammarstedt2012AdiposeTD,
  title={Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells},
  author={Ann Hammarstedt and Timothy E. Graham and Barbara B Kahn},
  booktitle={Diabetology & metabolic syndrome},
  year={2012}
}
BackgroundObesity contributes to Type 2 diabetes by promoting systemic insulin resistance. Obesity causes features of metabolic dysfunction in the adipose tissue that may contribute to later impairments of insulin action in skeletal muscle and liver; these include reduced insulin-stimulated glucose transport, reduced expression of GLUT4, altered expression of adipokines, and adipocyte hypertrophy. Animal studies have shown that expansion of adipose tissue alone is not sufficient to cause… CONTINUE READING
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