Adipose tissue-derived stem cells suppress acute cellular rejection by TSG-6 and CD44 interaction in rat kidney transplantation.

@article{Kato2014AdiposeTS,
  title={Adipose tissue-derived stem cells suppress acute cellular rejection by TSG-6 and CD44 interaction in rat kidney transplantation.},
  author={Taigo Kato and Masayoshi Okumi and Masahiro Tanemura and Koji Yazawa and Yoichi Kakuta and Kazuaki Yamanaka and Koichi Tsutahara and Yuichiro Doki and Masaki Mori and Shiro Takahara and Norio Nonomura},
  journal={Transplantation},
  year={2014},
  volume={98 3},
  pages={277-84}
}
BACKGROUND In addition to its abundance and easy accessibility, adipose tissue yields more potent immunoregulatory stem cells (adipose tissue-derived stem cells, ADSCs) than does bone marrow. However, the beneficial effects of ADSCs on alloreactivity are scarcely known. This study evaluated the beneficial effects of ADSCs in rat kidney transplantation and analyzed the underlying molecular mechanism. METHODS Dark Agouti rat kidneys were transplanted into Lewis rats. Autologous ADSCs (2×10… CONTINUE READING
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by suppressing Th 1 development and enhancing tolerogenicity

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