Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease.

@article{Yaez2006AdiposeTM,
  title={Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease.},
  author={Rosa Ya{\~n}ez and Mar{\'i}a Luisa Lamana and Javier Garc{\'i}a-Castro and Isabel Colmenero and Manuel Ram{\'i}rez and Juan Antonio Bueren},
  journal={Stem cells},
  year={2006},
  volume={24 11},
  pages={2582-91}
}
Previous studies have shown the relevance of bone marrow-derived MSCs (BM-MSCs) in controlling graft-versus-host disease (GVHD) after allogeneic transplantation. Since adipose tissue-derived MSCs (Ad-MSCs) may constitute a good alternative to BM-MSCs, we have expanded MSCs derived from human adipose tissue (hAd-MSCs) and mouse adipose tissue (mAd-MSCs), investigated the immunoregulatory properties of these cells, and evaluated their capacity to control GVHD in mice. The phenotype and… CONTINUE READING
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