Adipose-tissue-derived and Wharton's jelly-derived mesenchymal stromal cells suppress lymphocyte responses by secreting leukemia inhibitory factor.

@article{Najar2010AdiposetissuederivedAW,
  title={Adipose-tissue-derived and Wharton's jelly-derived mesenchymal stromal cells suppress lymphocyte responses by secreting leukemia inhibitory factor.},
  author={Mehdi Najar and Gordana Raicevic and Hicham Id Boufker and Hussein Fayyad-Kazan and C{\'e}cile De Bruyn and Nathalie Meuleman and Dominique Bron and Michel Toungouz and Laurence Lagneaux},
  journal={Tissue engineering. Part A},
  year={2010},
  volume={16 11},
  pages={3537-46}
}
Mesenchymal stromal cells (MSCs) possess immunomodulatory functions and have been proposed as a tool for managing or preventing graft-versus-host disease. Recently, adipose tissue (AT) and Wharton's jelly (WJ) have been reported as potential alternative MSC sources to bone marrow (BM). In this study, we investigated the capacity of MSCs derived from AT and WJ to modulate lymphocyte proliferation as well as their impact on regulatory T-cells. We also evaluated MSC expression of leukemia… CONTINUE READING