Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.

@article{Ying2017AdiposeTB,
  title={Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.},
  author={Wei Ying and Joshua Wollam and Jachelle M. Ofrecio and Gautam Bandyopadhyay and Dalila El Ouarrat and Yun Sok Lee and Da Young Oh and Pingping Li and Olivia Osborn and Jerrold M. Olefsky},
  journal={The Journal of clinical investigation},
  year={2017},
  volume={127 3},
  pages={1019-1030}
}
Tissue inflammation is a key component of obesity-induced insulin resistance, with a variety of immune cell types accumulating in adipose tissue. Here, we have demonstrated increased numbers of B2 lymphocytes in obese adipose tissue and have shown that high-fat diet-induced (HFD-induced) insulin resistance is mitigated in B cell-deficient (Bnull) mice. Adoptive transfer of adipose tissue B2 cells (ATB2) from wild-type HFD donor mice into HFD Bnull recipients completely restored the effect of… CONTINUE READING

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