Adipose tissue:Critical contributor to the development of prostate cancer.

  title={Adipose tissue:Critical contributor to the development of prostate cancer.},
  author={Hisanori Uehara and Tomoko Kobayashi and Minoru Matsumoto and Shunsuke Watanabe and Akiko Yoneda and Yoshimi Bando},
  journal={The journal of medical investigation : JMI},
  volume={65 1.2},
The prostate is surrounded by periprostatic adipose tissue. Although adipose tissue was thought to play limited physiological roles, it has recently been recognized as an active endocrine organ, secreting growth factors and adipokines. Epidemiologically, obesity is associated with prostate cancer progression. A major mechanism to explain the link between obesity and cancer includes the insulin and insulin-like growth factor (IGF)-1 axis, sex steroids, and adipokines. When prostate cancer cells… CONTINUE READING
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