Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.

@article{Vernochet2012AdiposespecificDO,
  title={Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.},
  author={C{\'e}cile Vernochet and Arnaud Mourier and Olivier Bezy and Yazm{\'i}n Macotela and J{\'e}r{\'e}mie Boucher and Matthew J Rardin and Ding Ding An and Kevin Y Lee and Olga Ilkayeva and Cristina Maria Zingaretti and Brice Emanuelli and Graham Smyth and Saverio Cinti and Christopher B. Newgard and Bradford W. Gibson and Nils-G{\"o}ran Larsson and C Ronald Kahn},
  journal={Cell metabolism},
  year={2012},
  volume={16 6},
  pages={
          765-76
        }
}
Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the role for adipose tissue mitochondria in the development of these disorders is currently unknown. To understand the impact of adipose tissue mitochondria on whole-body metabolism, we have generated a mouse model with disruption of the mitochondrial transcription factor A (TFAM) specifically in fat. F-TFKO adipose tissue exhibit decreased mtDNA copy number, altered levels of proteins of the… CONTINUE READING
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