Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis.

@article{Spicer1998AdiposeOG,
  title={Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis.},
  author={Leon J. Spicer and Cristina C. Francisco},
  journal={Biology of reproduction},
  year={1998},
  volume={58 1},
  pages={207-12}
}
Leptin, a recently-discovered hormonal product of the obese (ob) gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety. Although noninsulin-dependent diabetics are insulin-resistant and have greater levels of leptin than normal subjects, little evidence existed previously to support the notion that leptin can influence insulin action, particularly in the ovary. Therefore, we tested the hypothesis that leptin signals metabolic information to the… CONTINUE READING

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In contrast , leptin blocked ( p < 0.05 ) insulin - induced progesterone and androstenedione production by thecal cells .
ObesityNo subtypeleptin
Adipose obese gene product , leptin , inhibits bovine ovarian thecal cell steroidogenesis .
Leptin , a recently - discovered hormonal product of the obese ( ob ) gene , circulates in the blood at levels paralleling those of fat reserves and regulates satiety .
In contrast , leptin blocked ( p < 0.05 ) insulin - induced progesterone and androstenedione production by thecal cells .
leptinNo subtypeObesity
Leptin , a recently - discovered hormonal product of the obese ( ob ) gene , circulates in the blood at levels paralleling those of fat reserves and regulates satiety .
Adipose obese gene product , leptin , inhibits bovine ovarian thecal cell steroidogenesis .
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