Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span.

@article{Dixit2008AdiposeimmuneID,
  title={Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span.},
  author={Vishwa Deep Dixit},
  journal={Journal of leukocyte biology},
  year={2008},
  volume={84 4},
  pages={
          882-92
        }
}
Increasing evidence suggests a tight coupling of metabolic and immune systems. This cross-talk mediated by neuroendocrine peptides as well as numerous cytokines and chemokines is believed to be responsible for integrating energy balance to immune function. These neuroendocrine-immune interactions are heightened during the state of chronic positive energy balance, as seen during obesity, and negative energy balance caused by caloric restriction (CR). Emerging evidence suggests that obesity may… CONTINUE READING
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