Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets.

@article{Faleck2010AdiposeDP,
  title={Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets.},
  author={David M Faleck and K Ali and Regan Roat and Mark J. Graham and Roseanne M Crooke and R{\'u}bia Battisti and Edna E. Garc{\'i}a and Rexford S. Ahima and Yumiko Imai},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={299 2},
  pages={E249-57}
}
The excess accumulation of lipids in islets is thought to contribute to the development of diabetes in obesity by impairing beta-cell function. However, lipids also serve a nutrient function in islets, and fatty acids acutely increase insulin secretion. A better understanding of lipid metabolism in islets will shed light on complex effects of lipids on beta-cells. Adipose differentiation-related protein (ADFP) is localized on the surface of lipid droplets in a wide range of cells and plays an… CONTINUE READING

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