Adipose-derived stem cells ameliorate renal interstitial fibrosis through inhibition of EMT and inflammatory response via TGF-β1 signaling pathway.

@article{Song2017AdiposederivedSC,
  title={Adipose-derived stem cells ameliorate renal interstitial fibrosis through inhibition of EMT and inflammatory response via TGF-β1 signaling pathway.},
  author={Yan Yan Song and Changliang Peng and Shasha Lv and Jing Cheng and Shanshan Liu and Qing Wen and Guang-ju Guan and Gang Liu},
  journal={International immunopharmacology},
  year={2017},
  volume={44},
  pages={
          115-122
        }
}
Adipose-derived stem cells (ADSCs) have been successfully used to treat acute kidney injury or acute renal failure. However, the effect of ADSCs on treating renal interstitial fibrosis remains unknown. Here, we assessed the therapeutic efficacy of ADSCs on renal interstitial fibrosis induced by unilateral ureter obstruction (UUO) and explored the potential mechanisms. After 7days of UUO, rats were injected with ADSCs (5×106) or vehicle via tail vein. We found that ADSCs administration… CONTINUE READING