Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis.

@article{Ellis2010AdiposeAS,
  title={Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis.},
  author={Jessica M Ellis and Lei Li and Pei-Chi Wu and Timothy R. Koves and Olga Ilkayeva and Robert A. Moffitt Johns Hopkins University David Stevens and Steven M. Watkins and Deborah M. Muoio and Rosalind A Coleman},
  journal={Cell metabolism},
  year={2010},
  volume={12 1},
  pages={53-64}
}
Long-chain acyl-CoA synthetase-1 (ACSL1) contributes 80% of total ACSL activity in adipose tissue and was believed to be essential for the synthesis of triacylglycerol. We predicted that an adipose-specific knockout of ACSL1 (Acsl1(A-/-)) would be lipodystrophic, but compared to controls, Acsl1(A-/-) mice had 30% greater fat mass when fed a low-fat diet and gained weight normally when fed a high-fat diet. Acsl1(A-/-) adipocytes incorporated [(14)C]oleate into glycerolipids normally, but fatty… CONTINUE READING