Adipose Triglyceride Lipase (ATGL) Expression Is Associated with Adiposity and Tumor Stromal Proliferation in Patients with Pancreatic Ductal Adenocarcinoma.

@article{Grace2017AdiposeTL,
  title={Adipose Triglyceride Lipase (ATGL) Expression Is Associated with Adiposity and Tumor Stromal Proliferation in Patients with Pancreatic Ductal Adenocarcinoma.},
  author={Shane A Grace and Marshall W Meeks and Yongxin Chen and Mona L. Cornwell and Xianzhong Ding and Ping Hou and J. Rutgers and Susan E Crawford and Jinping Lai},
  journal={Anticancer research},
  year={2017},
  volume={37 2},
  pages={699-703}
}
BACKGROUND Obesity is an established risk factor for the development of pancreatic ductal adenocarcinoma (PDAC). However, the pathophysiology of how increased adiposity increases the risk for PDAC has not been fully elucidated. Adipose triglyceride lipase (ATGL) is a lipase that catabolizes triglyceride hydrolysis and has been implicated in the development of breast cancer. We hypothesized that overweight patients with PDAC would demonstrate higher tumor ATGL expression compared to non… CONTINUE READING