Adipose Tissue Inflammation and Increased Ceramide Content Characterize Subjects With High Liver Fat Content Independent of Obesity

@article{Kolak2007AdiposeTI,
  title={Adipose Tissue Inflammation and Increased Ceramide Content Characterize Subjects With High Liver Fat Content Independent of Obesity},
  author={M. Kolak and J. Westerbacka and V. Velagapudi and D. W{\aa}gs{\"a}ter and L. Yetukuri and J. Makkonen and A. Rissanen and A. H{\"a}kkinen and M. Lindell and R. Bergholm and A. Hamsten and P. Eriksson and R. Fisher and M. Ore{\vs}i{\vc} and H. Yki–J{\"a}rvinen},
  journal={Diabetes},
  year={2007},
  volume={56},
  pages={1960 - 1968}
}
  • M. Kolak, J. Westerbacka, +12 authors H. Yki–Järvinen
  • Published 2007
  • Biology, Medicine
  • Diabetes
  • OBJECTIVE— We sought to determine whether adipose tissue is inflamed in individuals with increased liver fat (LFAT) independently of obesity. RESEARCH DESIGN AND METHODS— A total of 20 nondiabetic, healthy, obese women were divided into normal and high LFAT groups based on their median LFAT level (2.3 ± 0.3 vs. 14.4 ± 2.9%). Surgical subcutaneous adipose tissue biopsies were studied using quantitative PCR, immunohistochemistry, and a lipidomics approach to search for putative mediators of… CONTINUE READING

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    References

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    SHOWING 1-10 OF 52 REFERENCES

    Obesity is associated with macrophage accumulation in adipose tissue.

    VIEW 6 EXCERPTS
    HIGHLY INFLUENTIAL

    Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects.

    VIEW 2 EXCERPTS

    Ceramides in insulin resistance and lipotoxicity.

    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL