Adipose Tissue Concentrations of Persistent Organic Pollutants and the Risk of Prostate Cancer

@article{Hardell2006AdiposeTC,
  title={Adipose Tissue Concentrations of Persistent Organic Pollutants and the Risk of Prostate Cancer},
  author={Lennart Hardell and S. O. Andersson and Michael Carlberg and Louise Bohr and Bert van Bavel and Gunilla Lindstr{\"o}m and Hel{\'e}n Bj{\"o}rnfoth and Claes Ginman},
  journal={Journal of Occupational and Environmental Medicine},
  year={2006},
  volume={48},
  pages={700-707}
}
Objective: We sought to study the concentrations of certain persistent organic pollutants with endocrine-disrupting properties in cases with prostate cancer and controls with benign prostate hyperplasia. Methods: Adipose tissue was obtained from 58 cases and 20 controls. Results: The median concentration among controls was used as cut-off in the statistical analysis. In the total material, a greater-than median concentration of PCB congener 153 yielded an odds ratio (OR) of 3.15 and 95… 
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  • L. Multigner, J. Ndong, P. Blanchet
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2010
TLDR
Findings support the hypothesis that exposure to environmental estrogens increases the risk of prostate cancer.
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Findings both from the observational and experimental studies suggest a role of non-dioxin-like PCB153 in the development of high-grade and fatal prostate cancer.
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TLDR
It is suggested that no overall association exists between prostate cancer and organochlorines at the levels measured in the study population.
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TLDR
The existing epidemiological data do not support the hypothesis that exposure to specific OCPs is associated with an increased incidence of PC in the general population, and pooled estimates using random effects model and heterogeneity between studies were found.
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1
2
3
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5
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References

SHOWING 1-10 OF 36 REFERENCES
Organochlorines and Risk of Prostate Cancer
TLDR
It is suggested that long-term, low-dose exposure to specific OCPs and PCBs in the general population may contribute to an increased risk of prostate cancer and supports further investigation in this area.
Concentrations of polychlorinated biphenyls in blood and the risk for testicular cancer.
TLDR
The role of foetal exposure to different PCB congeners in the aetiology of testicular cancer is elucidated through analysis of data for 37 congeners of PCBs.
Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.
TLDR
In cases only the concentration on lipid basis of cis-nonachlordane was significantly increased, whereas case mothers showed significantly increased concentrations of the sum of PCBs, HCB, trans- and cis- nonachlordsane, and the sumOf chlordanes.
A cohort study of farming and risk of prostate cancer in Iowa.
TLDR
Men whose usual occupation was farmer were at an increased risk of prostate cancer after adjustment for age, smoking, alcohol, and dietary factors and exclusion of well-differentiated, localized tumors slightly strengthened the association.
Cancer incidence in a cohort of licensed pesticide applicators in Florida.
TLDR
Cancers that have been associated with estrogen disrupters were found in male, but not female, pesticide applicators and the lack of soft tissue sarcoma is at odds with prior literature associated with the use of phenoxy herbicides.
Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems.
  • S. Safe
  • Biology
    Environmental health perspectives
  • 1993
TLDR
The results indicate that metabolic activation is not required for PCB toxicity, and the parent hydrocarbons are responsible for most of the biochemical and toxic responses elicited by these compounds.
An evaluation of proposed frameworks for grouping polychlorinated biphenyl (PCB) congener data into meaningful analytic units.
TLDR
Grouping with respect to degree of chlorination and the previously proposed framework based on enzyme induction, occurrence, and other toxicological aspects were the most useful approaches to reducing a large number of PCB congeners into meaningful analytic units.
Male reproductive health and environmental xenoestrogens.
TLDR
The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active environmental chemicals during fetal and childhood development.
...
1
2
3
4
...