Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity.

@article{Lee2016AdiposeNK,
  title={Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity.},
  author={Byung-Cheol Lee and Myung-Sunny Kim and Munkyong Pae and Yasuhiko Yamamoto and Delphine Eberl{\'e} and Takeshi Shimada and Nozomu Kamei and H J Park and Souphatta Sasorith and Ju Rang Woo and Jia You and William Mosher and Hugh J M Brady and Steven E. Shoelson and Jongsoon Lee},
  journal={Cell metabolism},
  year={2016},
  volume={23 4},
  pages={685-98}
}
Obesity-induced inflammation mediated by immune cells in adipose tissue appears to participate in the pathogenesis of insulin resistance. We show that natural killer (NK) cells in adipose tissue play an important role. High-fat diet (HFD) increases NK cell numbers and the production of proinflammatory cytokines, notably TNFα, in epididymal, but not subcutaneous, fat depots. When NK cells were depleted either with neutralizing antibodies or genetic ablation in E4bp4(+/-) mice, obesity-induced… CONTINUE READING
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Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity, Cell Metabolism

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