Adipose Mesenchymal Stromal Cells Isolated From Type 2 Diabetic Patients Display Reduced Fibrinolytic Activity

@inproceedings{Acosta2013AdiposeMS,
  title={Adipose Mesenchymal Stromal Cells Isolated From Type 2 Diabetic Patients Display Reduced Fibrinolytic Activity},
  author={Lina Paola Gonz{\'a}lez Acosta and Abdelkrim Hmadcha and Natalia Escacena and Inmaculada P{\'e}rez-Camacho and Antonio Mart{\'i}nez de la Cuesta and Rafael J. Ruiz-Salmer{\'o}n and Benoit R Gauthier and Bernat Soria},
  booktitle={Diabetes},
  year={2013}
}
Stem cells have been successfully used for the treatment of critical limb ischemia (CLI). We conducted a clinical trial to determine the feasibility of using autologous adipose-derived mesenchymal stromal cells (AdMSCs) for the treatment of CLI. Unexpectedly, two diabetic patients developed peripheral microthrombosis. This adverse effect, which contrasts with the reported antithrombotic properties of MSCs, may stem from the diabetic environment that alters the fibrinolytic activity of AdMSCs… CONTINUE READING
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