Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial.

  title={Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial.},
  author={Yves-Marie Pers and Lars Rackwitz and Rosanna Ferreira and Oliver Pullig and Christophe Delfour and F Barry and Luc Sens{\'e}b{\'e} and Louis Casteilla and Sandrine Fleury and Philippe Bourin and Dani{\'e}le No{\"e}l and François Canovas and Catherine Cyteval and Gina Lisignoli and Joachim H. X. Schrauth and Daniel C Haddad and Sophie Domergue and Ulrich Noeth and Christian Jorgensen},
  journal={Stem cells translational medicine},
  volume={5 7},
UNLABELLED : Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage associated with subchondral bone changes and synovial inflammation, causing pain and disability. The present study aimed at evaluating the safety of a dose-escalation protocol of intra-articular injected adipose-derived stromal cells (ASCs) in patients with knee OA, as well as clinical efficacy as secondary endpoint. A bicentric, uncontrolled, open phase I clinical trial was… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 17 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 45 extracted citations

Limited evidence for adipose-derived stem cell therapy on the treatment of osteoarthritis

Knee Surgery, Sports Traumatology, Arthroscopy • 2018
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 31 references

Secondlook arthroscopic evaluation of cartilage lesions aftermesenchymal stemcell implantation inosteoarthritic knees

YG Koh, YJ Choi, OR Kwon
Am J Sports Med • 2014

Treat - ment of knee osteoarthritis with autologous mesenchymal stem cells : Two - year follow - up results

JM Murphy, DJ Fink, EB Hunziker
Transplantation • 2014

Mesen - chymal stem cells in regenerative medicine applied to rheumatic diseases : Role of secretome and exosomes

P Mattar, K Bieback
Biochimie • 2013

treatment demonstrated favorable and sustainable therapeutic effect for Crohn ’ s fistula

BerenbaumF, J Grifka

Similar Papers

Loading similar papers…