Adipose-Derived Stem Cells Stimulate Regeneration of Peripheral Nerves: BDNF Secreted by These Cells Promotes Nerve Healing and Axon Growth De Novo

@inproceedings{Lopatina2011AdiposeDerivedSC,
  title={Adipose-Derived Stem Cells Stimulate Regeneration of Peripheral Nerves: BDNF Secreted by These Cells Promotes Nerve Healing and Axon Growth De Novo},
  author={Tatiana Lopatina and Natalia Kalinina and Maxim Karagyaur and Dmitry V. Stambolsky and K A Rubina and Alexander V Revischin and Galina Pavlova and Yelena V. Parfyonova and Vsevolod A. Tkachuk},
  booktitle={PloS one},
  year={2011}
}
Transplantation of adipose-derived mesenchymal stem cells (ASCs) induces tissue regeneration by accelerating the growth of blood vessels and nerve. However, mechanisms by which they accelerate the growth of nerve fibers are only partially understood. We used transplantation of ASCs with subcutaneous matrigel implants (well-known in vivo model of angiogenesis) and model of mice limb reinnervation to check the influence of ASC on nerve growth. Here we show that ASCs stimulate the regeneration of… CONTINUE READING
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