Adipose-Derived Mesenchymal Stem Cells (ADSCs) With the Potential to Ameliorate Platelet Recovery, Enhance Megakaryopoiesis, and Inhibit Apoptosis of Bone Marrow Cells in a Mouse Model of Radiation-Induced Thrombocytopenia.

@article{Zhang2016AdiposeDerivedMS,
  title={Adipose-Derived Mesenchymal Stem Cells (ADSCs) With the Potential to Ameliorate Platelet Recovery, Enhance Megakaryopoiesis, and Inhibit Apoptosis of Bone Marrow Cells in a Mouse Model of Radiation-Induced Thrombocytopenia.},
  author={Jiamin Zhang and Shi-yuan Zhou and Yi Zhou and Feier Feng and Qianming Wang and Xiaolu Zhu and Jingzhong Zhao and Haixia Fu and Meng Lv and Huisheng Ai and Xiaojun Huang and Xiaohui Zhang},
  journal={Cell transplantation},
  year={2016},
  volume={25 2},
  pages={261-73}
}
Substantial damage to the bone marrow can be caused by exposure to radiation, which can then develop into severe thrombocytopenia. In this study, we investigated the in vivo impact of adipose-derived mesenchymal stem cells (ADSCs) on megakaryopoiesis and platelet recovery in irradiated mice. Radiation markedly reduced peripheral blood counts. Recovery of both platelets and WBCs was better in the ADSC-treated group compared with the saline group and the fibroblast group 21 days after irradiation… CONTINUE READING