Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction

@inproceedings{Chen2011AdiposeDerivedMS,
  title={Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction},
  author={Yen-ta Chen and Cheuk-Kwan Sun and Yu-Chun Lin and Li-Teh Chang and Yung-Lung Chen and Tzu-hsien Tsai and S Y Chung and Sarah Chua and Ying-Hsien Kao and Chia-Hung Yen and P L Shao and Kuan-Cheng Chang and Steve Leu and Hon-Kan Yip},
  booktitle={Journal of Translational Medicine},
  year={2011}
}
Reactive oxygen species are important mediators exerting toxic effects on various organs during ischemia-reperfusion (IR) injury. We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) protect the kidney against oxidative stress and inflammatory stimuli in rat during renal IR injury. Adult male Sprague-Dawley (SD) rats (n = 24) were equally randomized into group 1 (sham control), group 2 (IR plus culture medium only), and group 3 (IR plus immediate intra-renal administration of 1… CONTINUE READING
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