Adipose‐derived stem cells as a new therapeutic modality for ageing skin

@article{Kim2011AdiposederivedSC,
  title={Adipose‐derived stem cells as a new therapeutic modality for ageing skin},
  author={Jae-Hong Kim and Minyoung Jung and Hyun-Soo Kim and Yong-Man Kim and Eung Ho Choi},
  journal={Experimental Dermatology},
  year={2011},
  volume={20}
}
Stem cells are undifferentiated cells, which have the important properties of self-renewal and differentiation. [] Key Result Subcutaneous injection of ADSC significantly increased collagen synthesis in hairless mice, and dermal thickness, collagen density and fibroblast number also increased. In addition, procollagen type I protein and mRNA expression increased, which accounts for the increased dermal collagen density.
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117 Citations
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117 Citations

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Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing
TLDR
ADSCs fulfill the general accepted criteria for cell-based therapies, but still need further investigations into their efficiency, taking into consideration the host-environment and patient-associated factors.
Effect of Adipose-derived Mesenchymal Stem Cells in Photoaging Balb/C Mouse Model
TLDR
Investigation of subcutaneous injection of ADSC showed that 1x104 ADSC subcutaneuous injection significantly increase collagen synthesis in Balb/C mice and collagen density in photoaging, and revealed that Adiposed-derived Mesenchymal stem cells stimulate colagen density, and improved photoaging.
Antiaging Properties of Exosomes from Adipose-Derived Mesenchymal Stem Cells in Photoaged Rat Skin
TLDR
It is demonstrated that ADSC-derived exosome treatment could significantly improve skin photodamage and thatADSC- derived exosomes may be a potential agent for photoaged skin treatment.
Protective effects of adipose-derived stem cells secretome on human dermal fibroblasts from ageing damages.
TLDR
The results suggest that ADSCs secretome protect HDFs from ageing damages but with some limitations, and ADSC-CM treatment can slightly or significantly improve cellular proliferative activity and restore functions both in irradiated and non-irradiated HDFs.
Skin Immunomodulation during Regeneration: Emerging New Targets
TLDR
The potential indicators of their immunomodulatory effect in skin regeneration and aging are explored and pathways involved such as Growth Differentiation Factor-11 (GDF11), Tumor Growth Factor (TGF)-β, Metalloproteinase (MMP), microRNA, and inflammatory cytokines that might serve as specific biomarkers of their Immunomodulating capacity are explored.
Application of adipose-derived stem cells in photoaging: basic science and literature review
TLDR
Compared with ADSCs alone, the secretome-based approaches and different preconditionings of ADSCs are more promising to overcome the current limitations and enhance the anti-photoaging capacity.
The effect of injection of ADSC compared to APPE on collagen density in aging skin (animal study)
TLDR
It is concluded that ADSC had anti-aging potential or regenerative by stimulating collagen synthesis of dermal fibroblast and will be as new modality treatment for aging skin in future.
Adipose-Derived Stem Cells Improve the Aging Skin of Nude Mice by Promoting Angiogenesis and Reducing Local Tissue Water.
TLDR
ASCs increased dermal thickness, promoted angiogenesis and reduced LTW in the skin of photoaging mice, providing a potential clinical therapy for skin rejuvenation.
Whitening Effects of Adipose-Derived Stem Cells: A Preliminary In Vivo Study
TLDR
The study findings suggest that ADSCs inhibit melanin formation induced by UV exposure, and potentially, ADSCs may be used as anti-aging agents, including skin whitening.
Equivalent effects of topically-delivered adipose-derived stem cells and dermal fibroblasts in the ischemic rabbit ear model for chronic wounds.
TLDR
ADSC and RDF can be delivered topically to wounds, resulting in a high level of engraftment in the ischemic background, and holds promise for chronic wound healing as well as other antiscarring therapies, but further studies are warranted before full clinical translation.
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References

SHOWING 1-10 OF 25 REFERENCES
Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts.
Antiwrinkle effect of adipose-derived stem cell: activation of dermal fibroblast by secretory factors.
Potential application of adipose-derived stem cells and their secretory factors to skin: discussion from both clinical and industrial viewpoints
TLDR
Application of ASCs and ASC-CM to dermatology shows promising results for skin regeneration, especially when culturing ASCs for the production of cosmetic raw materials and transduction of specific genes into ASCs may increase the regenerative protein content of the conditioned medium.
Mesenchymal stem cells: clinical applications and biological characterization.
  • F. Barry, J. Murphy
  • Biology, Medicine
    The international journal of biochemistry & cell biology
  • 2004
Whitening effect of adipose-derived stem cells: A critical role of TGF-β1
TLDR
Results indicate that secretary factors of ADSC inhibit melanin synthesis by down-regulating the expression of tyrosinase and TRP1, which are mainly mediated by TGF-β1.
Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis
TLDR
The data suggest that bone marrow‐derived mesenchymal stem cells promote wound healing through differentiation and release of proangiogenic factors.
Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue
TLDR
Both UCB and AT are attractive alternatives to BM in isolating MSC: AT as it contains MSCs at the highest frequency and UCB as it seems to be expandable to higher numbers.
Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure.
TLDR
Resection and tumescentliposuction seem to be preferable above ultrasound-assisted liposuction for tissue-engineering purposes, and ASC demonstrated chondrogenic and osteogenic differentiation potential.
Cell-assisted lipotransfer: supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection.
TLDR
Comparisons of histologic features and yield of adipose-derived stromal (stem) cells (ASCs) were compared between human aspirated fat and excised whole fat to suggest clinical potential of the CAL method for soft tissue augmentation and partly explain why transplanted aspiratedFat does not survive well.
Imiquimod-induced interleukin-1 alpha stimulation improves barrier homeostasis in aged murine epidermis.
TLDR
These studies provide further evidence for the role of reduced interleukin-1 alpha signaling in the decline of permeability barrier function in aged skin, and point to the potential use of cytokine augmentation in barrier dysfunction of the aged.
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