Adiponectin suppresses angiotensin II-induced inflammation and cardiac fibrosis through activation of macrophage autophagy.

@article{Qi2014AdiponectinSA,
  title={Adiponectin suppresses angiotensin II-induced inflammation and cardiac fibrosis through activation of macrophage autophagy.},
  author={Guan-Ming Qi and Li-xin Jia and Yulin Li and Hui-hua Li and Jie Du},
  journal={Endocrinology},
  year={2014},
  volume={155 6},
  pages={2254-65}
}
Previous studies have indicated that adiponectin (APN) protects against cardiac remodeling, but the underlying mechanism remains unclear. The present study aimed to elucidate how APN regulates inflammatory responses and cardiac fibrosis in response to angiotensin II (Ang II). Male APN knockout (APN KO) mice and wild-type (WT) C57BL/6 littermates were sc infused with Ang II at 750 ng/kg per minute. Seven days after Ang II infusion, both APN KO and WT mice developed equally high blood pressure… CONTINUE READING
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