Adiponectin stimulates prostaglandin E(2) production in rheumatoid arthritis synovial fibroblasts.

@article{Kusunoki2010AdiponectinSP,
  title={Adiponectin stimulates prostaglandin E(2) production in rheumatoid arthritis synovial fibroblasts.},
  author={Natsuko Kusunoki and Kanako Kitahara and Fumiaki Kojima and Nahoko Tanaka and Kaichi Kaneko and Hirahito Endo and Toru Suguro and Shinichi Kawai},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 6},
  pages={1641-9}
}
OBJECTIVE Adipokines may influence inflammatory and/or immune responses. This study was undertaken to examine whether adiponectin affects the production of prostaglandin E(2) (PGE(2)) by rheumatoid arthritis synovial fibroblasts (RASFs). METHODS Synovial tissue was obtained from patients with RA who were undergoing joint replacement surgery. Fibroblast-like cells from the third or fourth passage were used as RASFs. Expression of adiponectin receptor messenger RNA (mRNA) and protein was… CONTINUE READING
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