Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells.

@article{Ogunwobi2006AdiponectinSP,
  title={Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells.},
  author={Olorunseun Olatunji Ogunwobi and Ian L P Beales},
  journal={Regulatory peptides},
  year={2006},
  volume={134 2-3},
  pages={
          105-13
        }
}
Adiponectin is a recently described mediator secreted by adipose tissue. Here we report the growth promoting and pro-inflammatory actions of adiponectin on colonic epithelial cancer cells. Full-length and globular adiponectin produced an identical stimulation of HT-29 cell growth that was blocked by inhibition of adenylate cyclase and protein kinase A and partially inhibited by a pan-specific protein kinase C inhibitor, but was unaffected by specific inhibition of extracellular signal-related… CONTINUE READING