Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

@article{Yamauchi2002AdiponectinSG,
  title={Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase},
  author={Toshimasa Yamauchi and Junji Kamon and Yasuhiko Minokoshi and Yusuke Ito and Hironori Waki and Shinichi Uchida and Shigeo Yamashita and Mitsuhiko Noda and Satomi Kita and Kohjiro Ueki and Koji Eto and Yasuo Akanuma and Philippe Froguel and Fabienne Foufelle and Pascal Ferr{\'e} and David Carling and Saki Kimura and Ryozo Nagai and Barbara B. Kahn and Takashi Kadowaki},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={1288-1295}
}
Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism. However, the signaling pathways that mediate the metabolic effects of Ad remain poorly identified. Here we show that phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full-length Ad in the liver. In parallel with its activation of AMPK, Ad stimulates phosphorylation of… CONTINUE READING
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