Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

  title={Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase},
  author={T. Yamauchi and J. Kamon and Y. Minokoshi and Y. Ito and H. Waki and S. Uchida and S. Yamashita and M. Noda and S. Kita and K. Ueki and K. Eto and Y. Akanuma and P. Froguel and F. Foufelle and P. Ferr{\'e} and D. Carling and S. Kimura and R. Nagai and B. Kahn and T. Kadowaki},
  journal={Nature Medicine},
  • T. Yamauchi, J. Kamon, +17 authors T. Kadowaki
  • Published 2002
  • Biology, Medicine
  • Nature Medicine
  • Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism. However, the signaling pathways that mediate the metabolic effects of Ad remain poorly identified. Here we show that phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full-length Ad in the liver. In parallel with its activation of AMPK, Ad stimulates phosphorylation of… CONTINUE READING
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